Amitriptyline Common side effects of Amitriptyline include: drowsiness, dizziness, dry mouth, blurred vision, constipation, weight gain, and trouble urinating Serious side effects of Amitriptyline include: easy bruising, unusual bleeding, persistent heartburn, shaking, mask-like facial expressions, muscle spasms, severe stomach pain, decreased sexual ability or desire, enlarge or painful. Amitriptyline interacts with antidepressants like Cymbalta, Lexapro, and Zoloft. Learn what else amitriptyline can interact with. See the list of drugs that interact with Amitriptyline. Includes information on severity of interaction and the level of evidence for it. Use WebMD’s Drug Interaction Checker to identify potential interactions between medications, supplements, and foods. Reduce side effects and support safer treatment decisions. Amitriptyline is a tricyclic antidepressant used to treat depression and, off-label, conditions like insomnia, anxiety, migraines, and chronic pain. Amitriptyline Interactions There are 745 drugs known to interact with amitriptyline, along with 20 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 153 are major, 563 are moderate, and 29 are minor. Find patient medical information for Amitriptyline (Amitid, Elavil, Endep) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Taking amitriptyline together with medicines used during surgery may increase the risk of side effects. This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor. This medicine may cause some people to become drowsy. See documented drug interactions for Amitriptyline, grouped by severity with plain-language and clinical explanations and cited evidence. 745 medications are known to interact with amitriptyline. Includes: drug, food, pregnancy, breastfeeding and therapeutic duplication warnings.